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COVID-19 and Diabetes References

Updated : Aug/07/2020 , NP

Note :

Always consult a qualified medical practitioner before taking any new medication

If you are using any information given on this page, please do so at your risk.

  • This page is for my personal reference only due to the fact that there are many people amongst friends and family suffering from diabetes.
  • This is a compilation of my readings through latest papers published over last 6 months.

Tech Note: This page is not seen by any search engines including google (I’ve technically instructed them to ignore this page).

1. Top Bookmarks for COVID-19 – click here
2. Can I get some testing kits for COVID-19 ? click here
3. Can I get COVID-19 infection again ? – click here
4. Type 2 Diabetes –   आपसे नहीं होगा – click here
5. अगर आपको डायबिटीज है और साथ ही आपको लगता है कि आप Corona से संक्रमित है तो – click here

*COVID symptoms*

People with COVID-19 have had a wide range of symptoms reported – ranging from mild symptoms to severe illness. 

Symptoms may appear *2-14 days after exposure to the virus*. People with these symptoms may have COVID-19:

*SOME DIGESTIVE PROBLEMS*
  1. Diarrhea 
  2. Nausea or vomiting  
*SOME RESPIRATORY / BREATHING PROBLEMS*
  1. Cough
  2. Congestion or runny nose
  3. Shortness of breath or difficulty breathing
  4. Sore throat
*SOME OF OTHER PROBLEMS*
  1. Fatigue / Tiredness
  2. Muscle or body aches
  3. Headache
  4. Fever
  5. Chills (feeling cold)
  6. New loss of taste or smell (usually for asymptomatic patients ; further studies needed. )
*Look for emergency warning signs for COVID-19*

If someone is showing any of these signs, seek emergency medical care immediately

  1. Trouble breathing
  2. Persistent pain or pressure in the chest
  3. New confusion
  4. Inability to wake or stay awake
  5. Bluish lips or face
This list does not include all possible symptoms. CDC will continue to update this list as they learn more about COVID-19.  
 
*MUST KEEP THESE THINGS READY*
  1. Blood Pressure Measuring Machine
  2. Thermometer
  3. For diabetics, Glucometer with enough test-strips and lancets
  4. For diabetics, Recent A1C blood report 
*FIRST LINE OF THERAPY* (Always consult a doctor before taking any medicine)
  1. Aziththromycin
  2. HydroxyChloriquin (not for diabetic patient taking glucose medicines)

*Top References for COVID-19 medication – *University of Liverpool*

Must check the drug interaction (reaction) if you are taking more than one medicine.

  1. *COVID Drug Interaction Online Checker(best viewed in large screens)* – https://www.covid19-druginteractions.org/checker
  2. *COVID Drug Interaction Online Reference*   – 

Read using Google – https://docs.google.com/viewer?url=https%3A%2F%2Fliverpool-covid19.s3.eu-west-2.amazonaws.com%2Flanding-page%2FCovid_InteractionSummary_Web_2020_Mar18.pdf&embedded=true&chrome=false&dov=1

Download – https://liverpool-covid19.s3.eu-west-2.amazonaws.com/landing-page/Covid_InteractionSummary_Web_2020_Mar18.pdf

  1. *Top COVID Treatment Resources* 

HCQ alone gives meaningful control of glucose 

Cautiously use Metformin with HCQ or CQ


*Abstract*

The new study was published online on scientific pre-print server BioRxiv and shows that 30-40% of mice treated with a combination of HCQ or CQ and diabetes drug metformin, died. Treatment with the same dose of either drug alone had no effect on the survival of the mice.

HCQ – HydroxyChloroquin

CQ – Chloroquin

*References* –
  1. Researchers Warn Possible Coronavirus Treatment Hydroxychloroquine May Be Toxic When Combined With Diabetes Drug^ https://www.forbes.com/sites/victoriaforster/2020/04/05/researchers-warn-that-covid-19-treatment-touted-by-trump-may-be-toxic-when-combined-with-diabetes-drug/#5808e26055f8
  2. A New Drug–Drug Interaction between Hydroxychloroquine and Metformin? A Signal Detection Study | SpringerLink^ https://link.springer.com/article/10.1007/s40264-020-00955-y
  3. Two potential COVID-19 treatments could be deadly when combined with metformin – Diabetes^ https://www.diabetes.co.uk/news/2020/apr/two-potential-covid-19-treatments-are-deadly-combined-with-metformin.html
  4. Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice | bioRxiv^ https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1
  5. Drug interaction between hydroxychloroquine and metformin^ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290148/
  6. Potential Benefits and harms of Novel Anti-Diabetic drugs during COVID-19 Crisis

Read using Google –https://docs.google.com/viewer?url=https%3A%2F%2Fwww.mdpi.com%2F1660-4601%2F17%2F10%2F3664%2Fpdf&embedded=true&chrome=false&dov=1&urp=gmail_link

Download – https://www.mdpi.com/1660-4601/17/10/3664/pdf

*References for DPP-4 inhibitors, GLP1 receptor agonists, SGLT inhibitors*

Read using Google – https://docs.google.com/viewer?url=https%3A%2F%2Fwww.mdpi.com%2F1660-4601%2F17%2F10%2F3664%2Fpdf&embedded=true&chrome=false&dov=1

Download – https://www.mdpi.com/1660-4601/17/10/3664/pdf

Notable References: COVID-19

  1. COVID-19: How does Metformin interact with the new Coronavirus and why some persons are immune to it and others not?^https://www.researchgate.net/post/COVID-19_How_does_Metformin_interact_with_the_new_Coronavirus_and_why_some_persons_are_immune_to_it_and_others_not
  2. Potential drug–drug interactions associated with drugs currently proposed for COVID‐19 treatment in patients receiving other treatments – Lemaitre – – Fundamental & Clinical Pharmacology – Wiley Online Library^ https://onlinelibrary.wiley.com/doi/full/10.1111/fcp.12586
  3. SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done? | Immunity & Ageing | Full Text^ https://immunityageing.biomedcentral.com/articles/10.1186/s12979-020-00192-y
  4. A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study | SpringerLink^ https://link.springer.com/article/10.1007/s40264-020-00955-y
  5. The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial – Full Text View – ClinicalTrials.gov^ https://clinicaltrials.gov/ct2/show/NCT04364815
  6. Should anti-diabetic medications be reconsidered amid COVID-19 pandemic? – Diabetes Research and Clinical Practice^ https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(20)30396-X/fulltext

All about Hydroxychloroquin ;

See interactions section categorized as Level 1 (Severe), Level 2 (Major), Level 3 (Moderate), Level 4 (Minor)*
https://covid-19.elsevier.health/en-US/drug-monographs/hydroxychloroquine

Type-2 Diabetes Medication Choices in Non-COVID times

“*Diabetes Management Apps * “`    

*Track your daily diabetes data  – medication, sugar levels, exercise etc. and possibly predict your A1C*
  1. Diabetes:M – Management & Blood Sugar Tracker App – Apps on Google Play ^https://play.google.com/store/apps/details?id=com.mydiabetes&hl=en_US&showAllReviews=true
  2. mySugr – Diabetes App & Blood Sugar Tracker – Apps on Google Play ^https://play.google.com/store/apps/details?id=com.mysugr.android.companion&hl=en_US
  3. OneTouch Reveal® mobile app for Diabetes – Apps on Google Play ^https://play.google.com/store/apps/details?id=com.lifescan.reveal&hl=en_US
  4. Glucose Buddy Diabetes Tracker – Apps on Google Play ^https://play.google.com/store/apps/details?id=com.skyhealth.glucosebuddyfree&hl=en_US